This Baked Cajun Salmon recipe is your new weeknight dinner hero. It’s incredibly flavorful, ridiculously easy, and on the table in under 20 minutes. We’re talking tender, flaky salmon with a perfectly spicy, savory crust that will have everyone asking for seconds. Forget complicated meals; this is maximum flavor for minimal effort.
We combine a handful of simple spices to create a homemade Cajun seasoning that’s worlds better than store-bought. A drizzle of melted butter and a squeeze of fresh lemon juice is all it takes to create a mouthwatering sauce that keeps the salmon unbelievably moist. Let’s get cooking!
Why This Baked Cajun Salmon Recipe is a Winner
You’re going to absolutely love this dish, and here’s why it stands out from the rest:
- Fast and Effortless: This is the definition of a quick salmon dinner. With just 5 minutes of prep and about 15 minutes in the oven, it’s perfect for those busy weeknights when you need something delicious, fast.
- Bold, Authentic Flavor: Our simple homemade Cajun seasoning blend delivers a punch of savory, smoky, and slightly spicy flavor that perfectly complements the rich taste of salmon.
- Perfectly Cooked, Every Time: Say goodbye to dry, overcooked fish. We’ll share our secrets for baking salmon so it turns out perfectly flaky and moist every single time.
- Healthy and Versatile: Salmon is packed with omega-3s and protein. This recipe is naturally low-carb and gluten-free, making it a healthy choice you can feel good about serving.
The Simple Ingredients You’ll Need
The magic of this Cajun spiced salmon comes from a few pantry-staple ingredients. No need for a special trip to the store!

For the Salmon:
- Salmon Fillets: You’ll need four 6-ounce salmon fillets. Look for fillets that are similar in thickness to ensure they cook evenly. You can use skin-on or skinless, whichever you prefer.
- Unsalted Butter: Melted butter adds richness and helps keep the salmon moist.
- Garlic: Freshly minced garlic provides an aromatic depth of flavor.
- Lemon Juice: A squeeze of fresh lemon juice brightens everything up.
For the Homemade Cajun Seasoning:
- Smoked Paprika: The secret to that beautiful color and smoky flavor.
- Garlic Powder & Onion Powder: These form the savory base of our spice blend.
- Dried Thyme & Dried Oregano: Essential herbs that bring a classic Cajun aroma.
- Cayenne Pepper: This brings the heat! Feel free to adjust the amount to your personal preference.
- Salt & Black Pepper: To taste, to enhance all the other flavors.
How to Make Baked Cajun Salmon: Step-by-Step
Ready to see how easy this is? Let’s break it down into four simple steps.
- Prep the Oven and Salmon: First, preheat your oven to 400°F (200°C). Pat the salmon fillets completely dry with a paper towel. This is a crucial step to get a nice sear on the outside. Place them on a baking sheet lined with parchment paper for easy cleanup.
- Mix the Seasoning: In a small bowl, combine the smoked paprika, garlic powder, onion powder, thyme, oregano, cayenne pepper, salt, and black pepper. Stir until everything is well mixed.
- Season the Salmon: In another small bowl, whisk together the melted butter, minced garlic, and fresh lemon juice. Brush this butter mixture generously over the top and sides of each salmon fillet. Then, sprinkle the Cajun seasoning blend evenly over the fillets.
- Bake to Perfection: Place the baking sheet in the preheated oven and bake for 12-15 minutes. The exact time will depend on the thickness of your fillets. The salmon is done when it flakes easily with a fork.

Pro Tips for the Best Cajun Salmon Bake
Want to guarantee restaurant-quality results? Keep these simple tips in mind.
- Don’t Overbake: The number one rule for cooking salmon is not to overdo it. Check for doneness at the 12-minute mark. The fish should be opaque and flake easily. An instant-read thermometer is your best friend here; aim for an internal temperature of 140-145°F in the thickest part.
- Dry the Salmon Well: I mentioned it before, but it’s worth repeating. Patting the salmon dry ensures the butter mixture and spices adhere properly, creating that delicious crust we’re after.
- Use Fresh Lemon: While bottled lemon juice works in a pinch, the flavor of freshly squeezed lemon is so much brighter and makes a noticeable difference.
Delicious Serving Suggestions
This Baked Cajun Salmon is a fantastic centerpiece for a meal. You can pair it with almost anything! For a truly show-stopping dinner, try serving it alongside our creamy Creamy Garlic Parmesan Orzo. The rich, cheesy pasta is the perfect complement to the spicy salmon.
Other fantastic options include a side of Healthy Sautéed Vegetables for a light and balanced meal, or some fluffy rice to soak up the delicious pan juices. And if you’re feeling indulgent, a side of warm Butter Swim Biscuits is never a bad idea.
Variations and Substitutions
While this recipe is fantastic as is, feel free to make it your own!
- Adjust the Spice: If you’re sensitive to heat, reduce or omit the cayenne pepper. If you love it extra spicy, add a little more!
- Try Different Herbs: Don’t have thyme or oregano? Feel free to experiment with other herbs like dried parsley or a pinch of rosemary.
- Air Fryer Method: You can absolutely make this in an air fryer! Cook at 400°F (200°C) for 7-9 minutes, or until the salmon is cooked through.
Storing and Reheating Leftovers
If you have any leftover salmon, store it in an airtight container in the refrigerator for up to 3 days.
To reheat, it’s best to use the oven or a toaster oven to prevent it from drying out. Warm it at 275°F (135°C) for about 10-15 minutes, or until just heated through. Avoid the microwave if possible, as it can make the salmon rubbery.
FAQs About Baked Cajun Salmon
At 400°F (200°C), salmon fillets typically take 12-15 minutes to bake. The exact time depends on the thickness of your fillets. The salmon is done when it flakes easily with a fork.
The spice level is easily adjustable! Our recipe has a mild to medium kick from the cayenne pepper. You can reduce the amount for less heat or add more if you like it extra spicy.
Cajun salmon is incredibly versatile. It pairs wonderfully with creamy pasta, roasted vegetables, a fresh salad, or simple white rice. For a classic pairing, try serving it with dirty rice or grits.
Cajun seasoning is a rustic blend of spices. Our homemade version includes smoked paprika, garlic powder, onion powder, dried thyme, oregano, and cayenne pepper for a savory, smoky, and spicy flavor profile.
For tender and moist results, we recommend baking salmon at a high temperature of 400°F (200°C). This cooks the fish quickly, preventing it from drying out.
Your New Favorite Salmon Recipe Awaits
That’s all there is to it! A delicious, healthy, and incredibly fast Baked Cajun Salmon that’s perfect for any night of the week. Give this recipe a try and see just how easy it is to make a restaurant-quality meal at home. If you love it, please leave a comment below and share it on Pinterest for others to discover!

Baked Cajun Salmon

Baked Cajun Salmon: The Easiest 20-Minute Recipe
Ingredients
Equipment
Method
- Preheat your oven to 400°F (200°C). Line a baking sheet with parchment paper. Pat the salmon fillets completely dry with a paper towel and place them on the prepared baking sheet.
- In a small bowl, combine the smoked paprika, garlic powder, onion powder, thyme, oregano, cayenne pepper, salt, and black pepper. Stir until well mixed.
- In another small bowl, whisk together the melted butter, minced garlic, and fresh lemon juice. Brush this butter mixture generously over the top and sides of each salmon fillet. Sprinkle the Cajun seasoning blend evenly over the fillets.
- Place the baking sheet in the preheated oven. Bake for 12-15 minutes, depending on the thickness of your fillets. The salmon is done when it flakes easily with a fork and reaches an internal temperature of 145°F.
Notes
Tip 2: Patting the salmon fillets completely dry with a paper towel is the key to getting a perfectly seasoned crust.
Tip 3: Serve immediately with extra lemon wedges for squeezing over the top.